Intermediates
| INTERMEDIATE NAME | CAS NO | STRUCTURE | STATUS |
|---|---|---|---|
| Rivaroxaban Intermediates | |||
| 4-(4-Nitrophenyl)morpholine-3-one | 446292-04-2 |  |
Key Starting Material Commercial |
| 4-(4-Aminophenyl)morpholine-3-one | 438056-69-0 |  |
Key Starting Material Commercial (100% indigenous) |
| 5-Chlorothiophene-2-Carboxylic Acid | 24065-33-6 |  |
Intermediate/ Key Starting Material Commercial (100% indigenous) |
| (S)+-Glycidyl Phthalimide | 161596-47-0 |  |
Key Starting Material Commercial (100% indigenous) |
| 5-Chlorothiophene-2-CarbonylChloride | 42518-98-9 |  |
On Order (100% indigenous) |
| 2-[[(5S)-2-Oxo-3-[4-(3-oxo-4- morpholinyl)phenyl]-5-oxazolidinyl]methyl]- 1H-isoindole-1,3(2H)-dione | 446292-08-6 |  |
Intermediate Commercial (100% indigenous) |
| 4-[4-[(5S)-5-(Aminomethyl)-2-oxo-1,3- oxazolidin-3-yl]phenyl]morpholin-3-one hydrochloride | 898543-06-1 |  |
Intermediate Commercial (100% indigenous) |
| Sitagliptin Intermediates | |||
| 3-(Trifluoromethyl)-5,6,7,8-tetrahydro- [1,2,4]triazolo[4,3-α]pyrazine Hydrochloride | 762240-92-6 |  |
Intermediate/ Key Starting Material Commercial (100% indigenous) |
| (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5trifluorophenyl)butan-2-one (Sitagliptin Ketoamide) | 764667-65-4 |  |
Intermediate Commercial |
| (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1(2,4,5-trifluorophenyl)but-2-en-2-amine (Sitagliptin Enamine) | 767340-03-4 |  |
Intermediate Commercial |
| 3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5trifluorophenyl)-1-butanone (Racemic Sitagliptin) | 823817-56-7 |  |
Intermediate Commercial |
| (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4(2,4,5-trifluorophenyl)butan-1-one (Sitagliptin base) | 486460-32-6 |  |
Intermediate Commercial |
| Methyl 4-(2,4,5-trifluorophenyl)-3oxobutanoate | 769195-26-8 |  |
Key Starting Material On order 8-12WK Lead Time |
| (Z)-methyl 3-amino-4-(2,4,5trifluorophenyl)but-2-enoate | 881995-70-6 |  |
Key Starting Material On order 8-12WK Lead Time |
| Mirabegeron Intermediates | |||
| 2-(4-Nitrophenyl)ethylamine Hydrochloride (or) 4-Nitrophenethylamine Hydrochloride | 29968-78-3 |  |
Key Starting Material Commercial(100% indigenous) |
| 2-(2-Aminothiazol-4-yl) acetic acid hydrochloride (OR) 2-(2-Aminothiazol-4-yl) acetic acid (Free Base) | 66659-20-9 (OR) 29676-71-9 |  |
Key Starting Material Commercial(100% indigenous) |
| (R)-2-[[2-(4-Nitrophenyl)ethyl]amino]-1- phenylethanol hydrochloride | 521284-21-9 |  |
Advanced Intermediate On order 8-12 WK Lead time |
| (R)-2-[(2-(4-Aminophenyl)ethyl)amino]-1- phenylethanol hydrochloride | 521284-22-0 |  |
Advanced Intermediate On order 8-12 WK Lead time |
| Dofetilide Intermediates | |||
| N-Methyl-4-Nitrophenethylamine Hydrochloride | 166943-39-1 |  |
Key Starting Material Commercial (100% indigenous) |
| 1-(2-Chloroethoxy)-4-nitrobenzene | 3383-72-0 |  |
Key Starting Material Commercial (100% indigenous) |
| Deferasirox Intermediates | |||
| 4-Hydrazino Benzoic Acid | 619-67-0 |  |
INTERMEDIATE Commercial (100% indigenous) |
| Apixaban Intermediates | |||
| Acetic acid, 2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester | 27143-07-3 |  |
Key Starting Material Commercial (100% indigenous) |
| Teneligliptin Intermediates | |||
| 1-(3-Methyl-1-phenyl-5- pyrazolyl)piperazine (OR) 1-(3-Methyl-1-phenyl-5- pyrazolyl)piperazine Acetate | 401566-79-8 (OR) 906093-30-9 |  |
Key Starting Material Commercial (100% indigenous) |
| (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1- pyrrolidinecarboxylic acid tert-butyl ester | 401564-36-1 |  |
Key Starting Material Commercial |
| Apremilast Intermediates | |||
| 3-Acetamidophthalic anhydride | 6296-53-3 |  |
Key Starting Material Commercial (100% indigenous) |
| 3-Aminophthalic Acid | 5434-20-8 |  |
Key Starting Material Commercial |
| Vildagliptin/Anagliptin | |||
| (2S)-1-(2-Chloroacetyl)-2- pyrrolidinecarbonitrile | 207557-35-5 |  |
Key Starting Material/Intermediate Commercial |
| 1-Amino-3-adamantanol | 702-82-9 |  |
Key Starting Material/Intermediate Commercial |
| Linezolid | |||
| 3-Fluoro-4-(4-morpholinyl)aniline | 93246-53-8 |  |
Intermediate/ Key Starting Material Commercial |
| Safinamide | |||
| L-Alanamide Hydrochloride | 33208-99-0 |  |
Key Starting Material Lab Scale Completed 12-16 Wk Lead time |
| Pimavanserin | |||
| N-[(4-Fluorophenyl)methyl]-1-methyl-4- piperidinamine dihydrochloride | 1837794-51-0 |  |
Key Starting Material Lab Scale Completed 12-16 Wk Lead time(100% indigenous) |
| 4-Isobutoxybenzylamine Acetate | 955997-89-4 |  |
Key Starting Material Lab Scale Completed 12-16 Wk Lead time(100% indigenous) |
| Valbenazine/Tetrabenazine | |||
| 3,4-Dihydro-6,7-dimethoxyisoquinoline hydrochloride | 20232-39-7 |  |
Key Starting Material Lab scale completed |
| 3-[(Dimethylamino)methyl]-5-methyl-2- hexanone | 91342-74-4 |  |
Key Starting Material Lab Scale U/P |
| 1,2,3,4-Tetrahydro-6,7-isoquinolinediol Hydrobromide | 52768-23-7 |  |
Key Starting Material Lab scale completed |
| Tofacitinib | |||
| 4-Chloropyrrolo[2,3-d]pyrimidine | 3680-69-1 |  |
Key Starting Material Lab scale Initiated Launch Oct 2020(100% indigenous) |
| (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3- amine dihydrochloride. | 1062580-52-2 |  |
Key Starting Material/Intermediate Lab scale Initiated Launch Oct 2020 500 gm synthesized.(100% indigenous) |
| 1-Benzyl-4-methylpiperidin-3-one | 32018-96-5 |  |
Key Starting Material Launch Oct 2020 1000 gm Synthesized (100% indigenous) |
| Products Under development - Apixaban | |||
| 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo- 1-piperidinyl)phenyl]-2(1H)-pyridinone | 545445-44-1 |  |
Launch Dec 2020 Advanced Intermediate (100% indigenous) |
| 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2- oxopiperidin-1-yl)phenyl]-4,5,6,7- tetrahydro-1H-pyrazolo[3,4-c]pyridine-3- carboxylic acid ethyl ester | 503614-91-3 |  |
Launch Dec 2020 Advanced Intermediate (100% indigenous) |
